Bis(neopentyl glycolato)diboron → HCID 22329487, compound

HRID 2184057Notes

Reaction equation

HRID 2184057 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([F:14])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[N:10][CH:9]=2)[CH:7]=1.[B:15]1(B2OCC(C)(C)CO2)[O:20]CC(C)(C)C[O:16]1>>[F:14][C:5]1[CH:4]=[CH:3][C:2]([B:15]([OH:20])[OH:16])=[CH:7][C:6]=1[C:8]1[CH:13]=[CH:12][N:11]=[N:10][CH:9]=1

Participants

3

Reactant 2

HCID 2734316Bis(neopentyl glycolato)diboronHCID 22329512HCID 22329512, compound

Product 1

HCID 22329487HCID 22329487, compound

Procedure

4-(5-Bromo-2-fluorophenyl)pyridazine (1.0 g, 3.95 mmol) was reacted with bis(neopentyl glycolato)diboron (982 mg, 4.35 mmol) using the method in Example 51 to give 4-fluoro-3-(pyridazin-4-yl)phenylboronic acid: m/z (ES+) 219 (M++H).

Sources & evidence

ORD record
ord-cd28fc8e52644c8e804dcfa363e4af1d
Source dataset
uspto-grants-2005_05
Patent number
US06900215B2

Reaction notes

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