2-(3-Bromoimidazo[1,2-a]pyrimidin-7-yl)propan-2-ol → HCID 69707591, compound

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Reaction Steps

4-Fluoro-3-(pyridazin-4-yl)phenylboronic acid (100 mg, 0.46 mmol) was coupled to 2-(3-bromoimidazo[1,2-α]pyrimidin-7-yl)propan-2-ol (117 mg, 0.46 mmol) using the method in Example 1. Purification by chromatography on silica gel eluting with dichloromethane containing 5% methanol then trituration with diethyl ether gave 2-[3-(4-fluoro-3-(pyridazin-4-yl)phenyl)imidazo[1,2-α]pyrimidin-7-yl]propan-2-ol as a white solid: δH (400 MHz, CDCl3) 1.63 (6H, s), 7.11 (1H, d, J 7), 7.43-7.48 (1H, m), 7.64-7.69 (2H, m), 7.71-7.74 (1H, m), 7.88 (1H, s), 8.54 (1H, d, J 7), 9.33 (1H, dd, J 5 and 1), 9.46-9.47 (1H, m); m/z (ES+) 350 (M++H).

Provenance & Evidence