反应详情

Prepared in the manner of Example 23 except ethyl N-methyl-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}alaninate was substituted for ethyl N-methyl-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-glycinate. Purification by flash chromatography (4:1 hexanes/EtOAc) afforded the title compound as a pink oil (84%). 1H NMR (CDCl3) δ 7.48 (d, 2H), 6.86 (br d, 2H), 4.04 (m, 1H), 3.56 (m, 2H), 2.72 (s, 3H), 1.03 (d, 3H). Anal. Calc. C13H15NO2F6: C, 47.14; H, 4.56; N, 4.23. Found: C, 46.89; H, 4.61; N, 3.93. HRMS (MH+) Calc.: 332.1085. Found: 332.1073.

1. customPurification by flash chromatography (4:1 hexanes/EtOAc)