HCID 10384705, compound → HCID 22475630, compound

HRID 2184084Notes

Reaction equation

HRID 2184084 reaction equation
[CH3:1][N:2]([C:10]1[CH:15]=[CH:14][C:13]([C:16]([OH:25])([C:21]([F:24])([F:23])[F:22])[C:17]([F:20])([F:19])[F:18])=[CH:12][CH:11]=1)[CH2:3][CH2:4][C:5]([O:7]CC)=[O:6].CC1C=C(C([OH:42])(C(F)(F)F)C(F)(F)F)C=CC=1N[C@H](C(OCC)=O)C>>[OH2:6].[C:16]([OH:25])([C:21]([F:24])([F:23])[F:22])=[O:42].[CH3:1][N:2]([C:10]1[CH:15]=[CH:14][C:13]([C:16]([OH:25])([C:17]([F:20])([F:18])[F:19])[C:21]([F:23])([F:24])[F:22])=[CH:12][CH:11]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 10384705HCID 10384705, compoundHCID 86592173HCID 86592173, compound

Product 2

HCID 22392675Trifluoroacetic acid waterHCID 22475630HCID 22475630, compoundYield 99%

Procedure

Prepared in the manner of Example 20 step 3 except ethyl N-methyl-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-beta-alaninate was substituted for ethyl N-{2-methyl-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-phenyl}alaninate. Purification by reverse phase HPLC using a gradient elution of 80:20 H2O/TFA:CH3CN to 20:80 H2O/TFA:CH3CN at 254 nm afforded the title compound as a white solid (99%). MS (ES+) m/z 346 (MH+).

Workup

  1. customPurification by reverse phase HPLC
  2. washa gradient elution of 80:20 H2O/TFA

Sources & evidence

ORD record
ord-6fb553a636434bb790e678e58799554b
Source dataset
uspto-grants-2005_05
Patent number
US06900244B2

Reaction notes

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