反应详情

The product of step 1 (1.1 g, 5.6 mmol) was dissolved in methanol (50 mL) and 1M NaOH (17 mL) added. Allow reaction mixture to stir at ambient temperature over 18 hours. 10% Citric acid solution was added until a pH=4 was reached. Extract several times with EtOAc. The organic layer was washed several times with brine, dried (Na2SO4), filtered, and concentrated affording a quantitative yield of the title compound as a yellow oil. MS (ES+) m/z 166 (MH+).

1. customAllow reaction mixture
2. extractionExtract several times with EtOAc
3. washThe organic layer was washed several times with brine
4. dry with materialdried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated