HCID 10089688, compound → HCID 10410704, compound

Participants

Reaction Steps

Prepared in the manner of Example 34 except 1-(benzyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}amino)pentan-2-one was substituted for 1-(methyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}amino)-pentan-2-one. Purification by reverse phase HPLC using a gradient elution of 60:40 H2O/TFA:CH3CN to 0:100 H2O/TFA:CH3CN at 254 nm afforded the title compound as an yellow waxy solid (34%). 1H NMR (CDCl3) δ 7.48 (d, 2H), 7.33 (t, 2H), 7.27 (m, 1H), 7.20 (d, 2H), 6.81 (d, 2H), 4.70 (s, 2H), 4.03 (m, 1H), 3.56 (dd, 1H), 3.41 (dd, 1H), 1.50 (m, 4H), 0.97 (t, 3H). Anal. Calc. for C21H23NO2F6+0.1 TFA+0.5 H2O: C, 55.64; H, 5.35; N, 3.06. Found: C, 55.71; H, 5.56; N, 2.73. HRMS (MH+). Calc.: 436.1711. Found: 436.1728.

Provenance & Evidence