1-Chloro-4-[dichloro(4-methylphenyl)methyl]benzene → HCID 22475122, compound

HRID 2184100Notes

Reaction equation

HRID 2184100 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2)(Cl)Cl)=[CH:4][CH:3]=1.[F:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH2:26][CH2:27][N:28]([S:31]([C:34]3[CH:35]=[C:36]([OH:41])[C:37]([OH:40])=[CH:38][CH:39]=3)(=[O:33])=[O:32])[CH2:29][CH:30]=2)=[CH:21][CH:20]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:11]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=3)[O:40][C:37]3[CH:38]=[CH:39][C:34]([S:31]([N:28]4[CH2:27][CH:26]=[C:25]([C:22]5[CH:21]=[CH:20][C:19]([F:18])=[CH:24][CH:23]=5)[CH2:30][CH2:29]4)(=[O:33])=[O:32])=[CH:35][C:36]=3[O:41]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 224750011-Chloro-4-[dichloro(4-methylphenyl)methyl]benzeneHCID 22475147HCID 22475147, compound

Product 1

HCID 22475122HCID 22475122, compound

Procedure

Using 4-chlorophenyl-4-methylphenyl-dichloromethane (57 mg, 0.2 mmol) and 4-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-benzene-1,2-diol (69 mg, 0.2 mmol) as a starting material, the title compound was obtained as an off-white crystalline solid (90 mg, 80%) after taking the residue up in hexane/ethyl acetate (4/1), stirring for 10 minutes, filtering the solid and drying.

Sources & evidence

ORD record
ord-d36494f11c2e405cbe4ea1277a922477
Source dataset
uspto-grants-2005_05
Patent number
US06900227B2

Reaction notes

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