反应详情

温度

100 °C

To a stirred suspension of 2-fluorobenzeneboronic acid (280 mg, 2 mmol), Cs2CO3 (1.63 g, 5 mmol) and tetrakis(triphenylphosphine)palladium(0) (40 mg, 0.02 mmol) in toluene (35 ml) under nitrogen was added dropwise 2-fluorobenzoyl chloride (634 mg, 4 mmol). The suspension was heated at 100° C. for 16 h, cooled to RT and partitioned between ethyl acetate and water. The organic layer was washed with aqueous potassium hydrogencarbonate solution, brine, dried over sodium sulfate, filtered and evaporated. Purification by flash chromatography afforded the title compound (210 mg, 46%). Colorless liquid.

1. temperaturecooled to RT
2. custompartitioned between ethyl acetate and water
3. washThe organic layer was washed with aqueous potassium hydrogencarbonate solution, brine
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. customevaporated
7. customPurification by flash chromatography