Ethyl 3,4-Dihydroxybenzoate → 2,2-Bis-(3,5-difluoro-phenyl)-benzo[1,3]dioxole-5-carboxylic acid ethyl ester

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Reaction Steps

239 mg dichloro-bis(3,5-difluorophenyl)methane and 141 mg ethyl 3,4-dihydroxybenzoate were heated to 180° C. for 2 h 15 min. The brown mixture was diluted with dichloromethane, washed with sat. NaHCO3 solution and water. The dried solution was evaporated and the residue purified on silica gel to provide 284 mg resinous oil. MS: 419 ([M+H]+).

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