HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminopyridine → 2-(pyridin-4-ylamino)-6-(3,5-dimethoxyphenyl)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminopyridine | HCID 1727 | — |
| Reactant | Lithium hydride | HCID 62714 | — |
| Reactant | 2-(methylsulfanyl)-6-(3,5-dimethoxyphenyl)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one | HCID 11199113 | — |
| Product | 2-(pyridin-4-ylamino)-6-(3,5-dimethoxyphenyl)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one | HCID 9909136 | 92.7% |
Reaction Steps
Following the general procedure of Examples 2 and 3, 791.0 mg (8.404 mM) of 4-aminopyridine was reacted with 212.5 mg (26.73 mM) of lithium hydride and 3002.4 mg (8.4 mM) of 2-(methylsulfanyl)-6-(3,5-dimethoxyphenyl)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one to give 92.7% yield (95.9% purity) of 2-(pyridin-4-ylamino)-6-(3,5-dimethoxyphenyl)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06900316B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-7a340030bc6e4f4080979e85f55d788c |
| Source note | uspto-grants-2005_05 |