HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminopyridine → 2-(pyridin-4-ylamino)-6-(3,5-dimethoxyphenyl)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminopyridine | HCID 1727 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-(methylsulfanyl)-6-(3,5-dimethoxyphenyl)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one | HCID 11199113 | — |
| Product | 2-(pyridin-4-ylamino)-6-(3,5-dimethoxyphenyl)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one | HCID 9909136 | 66.3% |
Reaction Steps
By following the general procedure of Examples 2 and 3, 524.2 mg (5.569 mM) of 4-aminopyridine was reacted with 687.4 mg (17.2 mM) of sodium hydride and 1983.8 mg (5.550 mM) of 2-(methylsulfanyl)-6-(3,5-dimethoxyphenyl)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one to provide 66.3% yield (85.8% purity) of 2-(pyridin-4-ylamino)-6-(3,5-dimethoxyphenyl)-8-ethyl-8H-pyrido[2,3-d]pyrimidin-7-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06900316B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-bbf2260b2aca4d57a5e1553b97426582 |
| Source note | uspto-grants-2005_05 |