4-Methyl-3-nitrobenzonitrile → 3-Amino-4-methylbenzonitrile

Participants

Reaction Steps

120 g of 3-nitro-4-methylbenzonitrile were suspended in 1.2 l of EtOH and hydrogenated with 50 l of hydrogen at RT in the presence of 7 g of Pd/C (10%). After removal of the catalyst on Celite, the solvent was stripped off to result in 95 g of pure product (97%). 1H-NMR (DMSO-d6; δ in ppm): 7.1 (dd, 1H); 6.90 (d, 1H); 6.85 (dd, 1H); 5.35 (s, 2H, NH2); 2.15 (s, 3H)

Provenance & Evidence