HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxygen → 3-Ethoxy-4-methylbenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxygen | HCID 977 | — |
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Hydroxy-4-methylbenzonitrile | HCID 17750920 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Ethoxy-4-methylbenzonitrile | HCID 22476103 | 72.8% |
Reaction Steps
10 g (75 mmol) of 4-methyl-3-hydroxybenzonitrile were deprotonated with 1 eq. of NaH in 100 ml of DMF and then ethylated on the oxygen with 112 mmol of iodoethane. 8.8 g of product were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06900319B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-4cfb28f9a1c144d19bd84868cb31b766 |
| Source note | uspto-grants-2005_05 |