HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-(Aminomethyl)-2-methoxybenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Ammonia methanol | HCID 21705897 | — |
| Reactant | 4-(Bromomethyl)-2-methoxybenzonitrile | HCID 21985007 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(Aminomethyl)-2-methoxybenzonitrile | HCID 22476146 | — |
Reaction Steps
2.5 g of the bromide (b) were introduced into 10 ml of MeOH, and NH3 was passed in during dropwise addition of 38 ml of conc. ammonia/MeOH 1:1. After 2 h, the solvent was stripped off, the product was taken up in DCM and washed with water, and the organic phase was dried over Na2SO4. The product was precipitated as hydrochloride with ethereal HCl.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06900319B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-468f7783115645468e78014cd7b0fcff |
| Source note | uspto-grants-2005_05 |