HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 22476136, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2-Pyridinecarboxamide,5-cyano-(9CI) | HCID 11275086 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 22476136 | HCID 22476136 | — |
Reaction Steps
67 g (0.46 mol) of 5-cyanopyridine-2-carboxamide (Chem. Ber. 117 (1984) 1259) were suspended in 1 l aqueous methanol (1/1) and 84.7 ml (1.9 equivs.) of conc. HCl, 21,4 g of 10% strength Pd/C were added and hydrogenation was carried out in a shaken vessel at room temperature for 5 h (H2 uptake: 23.2; l theory: 22.3 l). The product dissolved during the hydrogenation (and the catalyst changed from gray to black). TLC (CH2Cl2/MeOH 9/1, NH3-saturated) revealed only traces of starting material.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06900319B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-37907862875f4cc5af749a09360bdc54 |
| Source note | uspto-grants-2005_05 |