Hydrochloric Acid → HCID 178419062, compound

Participants

Reaction Steps

A solution of 6-[(2,2-diphenylethyl)amino]-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2-carbonitrile (Preparation 12 or 13) (17 g, 40.1 mmol) and ethanol (850 ml) was treated with 2 N aqueous hydrochloric acid solution (50 ml) and the mixture stirred at room temperature for 24 hours. The solvent was removed under reduced pressure, the residue dissolved in ethanol and the solvent again removed under reduced pressure. The residue was triturated with diethyl ether, filtered, washed with diethyl ether and pentane and dried to afford the title compound as a solid (13.6 g).

Provenance & Evidence