反应详情

温度

100 °C

To a suspension of 5,6-diamino-nicotinic acid ethyl ester (1 eq., 5.0 g) in cyclohexanone (50 ml) bromobutanone (1.4 equiv., 5.95 g) was added over 15 min. The dark brown mixture was heated to 100° C. (inner temperature) and stirred 1.5 h at this temperature. The mixture was cooled to room temperature and the light brown solid was filtered off and was washed with TBME (20 ml). Drying under reduced pressure at 45° C. Yield: 5.06 g (65%).

1. additionwas added over 15 min
2. temperatureThe mixture was cooled to room temperature
3. filtrationthe light brown solid was filtered off
4. washwas washed with TBME (20 ml)
5. customDrying under reduced pressure at 45° C