2-Butanone, 3-bromo- → 8-Amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide

Participants

Reaction Conditions

Reaction Steps

5,6-Diamino-nicotinamide (30.0 g; 0.183 mol; 1.0 equiv) was suspended in cyclohexanone (280 mL). 3-Bromo-2-butanone (24 mL; 0.22 mol; 1.2 equiv) was added and the mixture was heated for 4 h to 100° C. The reaction mixture was cooled to 20° C. and allowed to stir for another 2 h. The solid was filtered off, washed with TBME (200 mL) and dried to yield 48.4 g of the title compound. Yield: 78%.

Provenance & Evidence