Ethyl 4-(2-aminoethyl)benzoate → Ethyl acetate hexane

Participants

Reaction Conditions

Reaction Steps

1.98 g (9.59 mmol) (S)—O-Benzyl-dihydro-5-hydroxymethyl-2(3H)furanone and 3.14 g (16.25 mmol) ethyl p-aminoethylbenzoate were dissolved in 50 mL THF and stirred at 50° C. for 20 hours. Reaction was concentrated and crude residue purified via chromatography, eluting with 50% ethyl acetate/hexane yielding 2.24 g (5.61 mmol, 58% yield) N′-[2-(4-carboethoxyphenyl)ethyl]-5-benzyloxy-4-hydroxypentanamide as a white solid. Step 3

Provenance & Evidence