Hexamethyldisilane → (11E)-Hexadec-11-en-1-yl acetate

Temperature

0 °C

FIG. 4 shows the reaction path for producing E-11-hexdecenyl acetate. To a dry 50-mL round-bottomed flask is added 4.5 g (0.026 mol) 7-octenyl acetate, 3.3 g (0.026 mol) 1,2-epoxy-5-cyclooctene and a magnetic stir bar. The solution is cooled to 0° C. and sparged with nitrogen for 10 minutes. Grubbs catalyst 848 (1.12 g, 1.31 mmol) is added and the reaction is stirred at 0° C. for 24 hours. The reaction is quenched by addition of 15 ml of 2M THP in IPA solution, warmed to 60° C. with stirring for 24 hours. Water (5 mL) is added and stirred vigorously for 10 minutes. The aqueous layer is separated, and the product washed with brine solution and dried over sodium sulfate. The product is purified by vacuum distillation, and then hydrogenated using 10% palladium on carbon with a 5 psi overpressure of hydrogen. The catalyst is filtered off without further purification. The epoxide is converted to the trans olefin as described in J. Amer. Chem. Soc. 98, 1265 (1976); J. Org. Chem. 41, 3063 (1976); Chem. Commun. 168 (1980)). 11,12-Epoxy-hexadecyl acetate is treated with 3.87 g (0.026 mol) hexamethyldisilane and 3.34 g (0.026 mol) potassium methoxide at room temperature (about 25° C.). The solution is warmed to 50° C. and stirred until the starting materials are consumed. The mixture is quenched with water and the organic phase is washed with 1 M hydrochloric acid, saturated aqueous solution of sodium bicarbonate, and finally brine. The organic phase is dried over sodium sulfate and vacuum distilled to yield E-11-hexadecenyl acetate.

1. customsparged with nitrogen for 10 minutes
2. customThe reaction is quenched by addition of 15 ml of 2M THP in IPA solution
3. temperaturewarmed to 60° C.
4. stirringwith stirring for 24 hours
5. additionWater (5 mL) is added
6. stirringstirred vigorously for 10 minutes
7. customThe aqueous layer is separated
8. washthe product washed with brine solution
9. dry with materialdried over sodium sulfate
10. distillationThe product is purified by vacuum distillation
11. filtrationThe catalyst is filtered off without further purification
12. temperatureThe solution is warmed to 50° C.
13. stirringstirred until the starting materials
14. customare consumed
15. customThe mixture is quenched with water
16. washthe organic phase is washed with 1 M hydrochloric acid, saturated aqueous solution of sodium bicarbonate, and finally brine
17. dry with materialThe organic phase is dried over sodium sulfate and vacuum
18. distillationdistilled

ORD record

ord-9c06fe80f1da44a7b1fc976baab6e537

Source dataset

uspto-grants-2005_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06900347B2