3-{4-[(3-Fluorophenyl)methoxy]phenyl}-2-methylprop-2-enamide → HCID 22476632, compound

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Reaction Steps

A solution of 50 mg of 3-[4-(3-fluoro-benzyloxy)-phenyl]-2-methyl-acrylamide in 10 ml methanol is treated with 4 mg of platinum dioxide and hydrogenated at RT and normal pressure for about 4 h. The catalyst is filtered off and the filtrate evaporated to dryness. Trituration of the residue in about 2 ml diethylether yields 12 mg (23%) of a colorless solid. MS: m/e=288.2 (M++H).

Provenance & Evidence