HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 3-[4-(3,4-Difluoro-benzyloxy)-phenyl]-propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(Bromomethyl)-1,2-difluorobenzene | HCID 581436 | — |
| Reactant | Phloretamide | HCID 16222514 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 3-[4-(3,4-Difluoro-benzyloxy)-phenyl]-propionamide | HCID 10379511 | 41.3% |
Reaction Steps
A mixture of 106 mg (0.64 mmol) 3-(4-hydroxy-phenyl)-propionamide, 178 mg (1.29 mmol) potassium carbonate and 140 mg (0.68 mmol) 3,4-difluorobenzyl bromide in 5 ml ethyl methyl ketone is hold at 50° C. for 24 hours. The reaction mixture is cooled, diluted with water and extracted with diethyl ether. Crystallization from n-hexane yields 77 mg (41%) of a colorless solid. MS: m/e=291.3 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06900354B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-29f34c6e629b400287a02cd3df9360c4 |
| Source note | uspto-grants-2005_05 |