Hydrochloric Acid → 3-[4-[(3-fluorophenyl)methoxy]phenyl]prop-2-enoic Acid

Participants

Reaction Conditions

Reaction Steps

6.48 g (17 mmol) 3-[4-(3-fluoro-benzyloxy)-phenyl]-acrylic acid 3-fluoro-benzyl ester is dissolved in 100 ml THF and 1.36 g (34 mmol) solid sodium hydroxide is added. The reaction mixture is heated overnight at 50° C., cooled and acidified with 1N hydrochloric acid. The precipitate is filtered off and washed with cold water to give 4.43 g (96%) of a colorless solid. MS: m/e=271.2 (M−H).

Provenance & Evidence