HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 68669331, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(Bromomethyl)-4-(trifluoromethyl)benzene | HCID 123062 | — |
| Reactant | 3-(4-Hydroxyphenyl)-N-methylprop-2-enamide | HCID 54400570 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | HCID 68669331 | HCID 68669331 | 70.5% |
Reaction Steps
195 mg (1.1 mmol) 3-(4-hydroxy-phenyl)-N-methyl-acrylamide is dissolved in 25 ml ethyl methyl ketone and 304 mg (2.2 mmol) potassium carbonate is added, followed by 289 mg (1.2 mmol) of 4-(trifluoromethyl)benzyl bromide. The reaction mixture is stirred overnight at RT, heated to 50° C. for 3 hours, treated with water and extracted 3 times with dichloromethane. The extract is dried over magnesium sulfate, concentrated and treated with ether to yield 260 mg (70%) of a colorless solid. MS: m/e=336.1 (M++H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06900354B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-e996b2e172934bdcb7d095a644c19511 |
| Source note | uspto-grants-2005_05 |