3-Methoxybenzyl bromide → 3-{4-[(3-Methoxyphenyl)methoxy]phenyl}-N-methylprop-2-enamide

HRID 2184370Notes

Reaction equation

HRID 2184370 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]([NH:12][CH3:13])=[O:11])=[CH:4][CH:3]=1.Br[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[CH:17]=1>>[CH3:23][O:22][C:18]1[CH:17]=[C:16]([CH:21]=[CH:20][CH:19]=1)[CH2:15][O:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]=[CH:9][C:10]([NH:12][CH3:13])=[O:11])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 40672073-Methoxybenzyl bromideHCID 544005703-(4-Hydroxyphenyl)-N-methylprop-2-enamide

Product 1

HCID 686685043-{4-[(3-Methoxyphenyl)methoxy]phenyl}-N-methylprop-2-enamideYield 60%

Procedure

The title compound is prepared in analogy to example 11 b) from 3-(4-hydroxy-phenyl)-N-methyl-acrylamide and 1-bromomethyl-3-methoxy-benzene. Yield=60%. Colorless solid. MS: m/e=298.2 (M++H).

Sources & evidence

ORD record
ord-9a209f92c97e4bc1afd07b44429ca69b
Source dataset
uspto-grants-2005_05
Patent number
US06900354B2

Reaction notes

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