HCID 22476603, compound → HCID 22476564, compound

Participants

Reaction Steps

[2-Fluoro-2-(4-nitrophenyl)cyclohexyl][(methylethyl)sulfonyl]amine (prepared in example 6) is diluted with ethanol and was transferred to a Parr bottle containing 1.25 g of 5% Pd on C (rinsed in with 5 mL of THF) under nitrogen (total ethanol=45 mL). The reaction mixture is then hydrogenated for 16-20 hours at 20-25° C. The reaction mixture is then filtered and the filtrate concentrated under vacuum. The residue can then be purified by flash chromatography on silica gel with ethyl acetate/hexanes to provide the final title compound.

Provenance & Evidence