HCID 22476602, compound → HCID 22476611, compound

Participants

Reaction Steps

Into a 500 mL single neck flask (2-hydroxycyclohexy)[(methylethyl)sulfonyl]amine (6.78 g, 30.6 mmol) was combined with pyridinium chlorochromate (7.92 g, 1.2 eq) in methylene chloride (300 mL) and stirred at room temperature under a nitrogen atmosphere for 4 hours. The solution was then filtered over a Celite® mat and the organic layer was washed once with water, dried over potassium carbonate, filtered, and concentrated under reduced vacuum to yield 13.42 g as a dark oil. This material was purified via silica gel chromatography employing the Water's Prep. 2000 and eluting with a solvent of methylene chloride/ethyl acetate 19:1 to yield the intermediate title compound (3.95 g, 59%). as a white solid. Ion Spray M.S. 218 (M*−1). Calculated for C9H17NO3S: Theory: C 49.29, H 7.81, N 6.39. Found: C 49.25, H 7.58, N 6.32.

Provenance & Evidence