HCID 22476579, compound → HCID 10267727, compound

Participants

Reaction Steps

{2-Hydroxy-2-[4-(phenylmethoxy)phenyl]cyclohexyl}[(methylethyl)sulfonyl]amine (5.00 g, 12.8 mmol) was combined with 5% palladium on carbon in ethyl acetate (200 mL) mixed together and placed on the power shaker under a hydrogen atmosphere at 45 psl's overnight. The solution was filtered over a Celite® mat and the resulting filtrate was concentrated under reduced vacuum to yield 4.1 g as a white solid. This material was purified via silica gel chromatography employing the Water's prep. 2000 while eluting with a solvent of methylene chloride/methanol 9:1 to provide the title compound (3.75 g 94%) as a white solid. Ion Spray M.S. 312.1 (M*−1). Calculated for C15H23NO4S: Theory: C 57.48, H 7.40, N 4.47. Found: C 57.11, H 7.40, N 4.65.

Provenance & Evidence