Potassium Carbonate → HCID 22476609, compound

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Reaction Steps

[2-hydroxy-2-(4-hydroxyphenyl)cyclohexyl][(methylethyl)sulfonyl]amine (3.40 g, 10.9 mmol), bromoacetonitrile (1.44 g, 1.1 eq) and potassium carbonate (1.80 g, 1.2 eq) were combined in acetone (20 mL) and stirred overnight at room temperature under a nitrogen atmosphere. The solution was then filtered and the filtrate was concentrated under reduced vacuum to yield 3.71 g as a brown oil. This material was purified via silica gel chromatography employing the Water's Prep. 200 while eluting with a solvent of hexane/ethyl acetate 3:2 to yield the intermediate title compound (2.52 g, 67%) as a tan solid. Ion spray M.S. 351.2 (M*−1). Calculated for C17H24N2O4S: Theory: C 57.93, H 6.86, N 7.95. Found: C 57.61, H 6.84, N 8.12.

Provenance & Evidence