1-(2-Hydroxyethyl)piperazine → HCID 10189014, compound

HRID 2184461Notes

Reaction equation

HRID 2184461 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:4][C:3]=1[C:18]([N:20]1[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[CH2:24][N:23]2[C:31]([C:34]([OH:36])=O)=[CH:32][CH:33]=[C:22]2[CH2:21]1)=[O:19].[OH:37][CH2:38][CH2:39][N:40]1[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:4][C:3]=1[C:18]([N:20]1[C:26]2[CH:25]=[CH:30][CH:29]=[CH:28][C:27]=2[CH2:24][N:23]2[C:31]([C:34]([N:43]3[CH2:44][CH2:45][N:40]([CH2:39][CH2:38][OH:37])[CH2:41][CH2:42]3)=[O:36])=[CH:32][CH:33]=[C:22]2[CH2:21]1)=[O:19]

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 21947850HCID 21947850, compound

Product 1

HCID 10189014HCID 10189014, compound

Procedure

The title compound was prepared from 10-{[2-chloro-4-(naphthalen-1-yl)phenyl]carbonyl}-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxylic acid of Step C and 1-(2-hydroxyethyl)-piperazine in the manner of Example 1, Step G.

Sources & evidence

ORD record
ord-6ef967ceaafe44cc9deef20116fd30c5
Source dataset
uspto-grants-2005_05
Patent number
US06900200B2

Reaction notes

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