Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 2,2,2-Trifluoroethanol | HCID 6409 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2-((R)-((3-Methyl-4-nitro-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole | HCID 46947529 | — |
| Product | Dexlansoprazole Sesquihydrate | HCID 71587692 | 90% |
Reaction Steps
A solution of compound (II) (1.42 Kg) in 2,2,2-trifluoroethanol (6.40 L) is treated with potassium hydroxide (1.31 Kg). The reaction mixture is left to react at 90° C. for 1.5 hours and then cooled to 25° C. Water and toluene are added to the reaction mixture and the two newly formed phases are separated. Pure crystalline Dexlansoprazole sesquihydrate (1.56 Kg, 90% yield) can be isolated from the organic phase following the procedure reported in Example 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08198455B2 |
|---|
| Source dataset | uspto-grants-2012_06 |
|---|
| ORD ID | ord-efd6a9e2354b4d0f831645bed8f05878 |
|---|
| Source note | uspto-grants-2012_06 |
|---|
