Hydrochloric Acid → 6-Fluoro-(3-pyrrolidinyl)-1,2-benzisoxazole hydrochloride

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(6-fluoro-1,2-benzisoxazol-3-yl)-1-pyrrolidinylcarboxylic acid ethenyl ester (5.1 g, 18.4 mmol, hydrochloric acid (5 ml), and isopropyl alcohol (50 ml) was heated at reflux for 3.5 hours. At the end of the reaction, the solvent was reduced to about 30 ml on a rotary evaporator and the mixture was cooled to 0° C. for 2 hours. The crystals were collected by filtration and rinsed with cold isopropyl alcohol. The 6-fluoro-3-(3-pyrrolidinyl)-1,2-benzisoxazole hydrochloride product weighed 3.09 g (69%). m.p.=225°-227° C. ANALYSIS: Calculated for C11H11FN2O.HCl: 54.44%C 4.99%H 11.54%N Found: 54.35%C 4.99%H 11.38%N

Provenance & Evidence