HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]phthalimide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5-HT6/7 antagonist 1 | HCID 9865357 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | N-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]phthalimide hydrochloride | HCID 18467219 | — |
Reaction Steps
To a solution of 8.0 g of N-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]phthalimide in dichloromethane/ethanol (150 ml) was added 1M—HCl in ether. The salt crystallized out rapidly. It was filtered off, washed with ethanol and dried to afford 8.15 g with m.p.=257°-259° C., dec. Recrystallization provided 7.20 g of pure white salt, with m.p. unchanged. ANALYSIS: Calculated for: C22H20FN3O3.HCl 61.47%C 4.92%H 9.77%N Found: 61.12%C 5.21%H 9.58%N
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE037729E1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-fda528e81e524319b6c7422e8fa44ce6 |
| Source note | uspto-grants-2002_06 |