Acetonitrile → [4-(6-Fluoro1H-indazol-3-yl)-1-piperazinyl]acetonitrile

Participants

Reaction Steps

A mixture of 6-fluoro-3-(4-piperazinyl)-1H-indazole (6.0 g, 2.7 mmol), NaHCO3 (2.5 g, 3.0 mmol) chloroacetonitrile (2.5 g, 3.3 mmol) and CH3CN (150 mol) was stirred at reflux under N2 for 18 hours. The cooled reaction was poured into H2O and the aqueous solution was extracted with EtOAc. The EtOAc extract was washed with H2O, washed with brine, dried with MgSO4 and concentrated to yield 7.0 g of a tan solid. A 1.3 g sample was recrystallized from EtOAc to yield 0.65 g of a beige solid, m.p. 154°-156° C. ANALYSIS: Calculated for C13H14FN3: 60.22%C 5.44%H 27.01%N Found: 59.97%C 5.55%H 26.91%N

Provenance & Evidence