Carbon Tetrachloride → HCID 21339854, compound

Participants

Reaction Conditions

Reaction Steps

Compound 3 (3.0 g, 9.79 mmol) and N-chloro-succinimide (3.27 g, 24.48 mmol) were dissolved in carbon tetrachloride (20 ml). The mixture was degassed and heated/irradiated by an IR lamp to reflux under argon. After 4 hours, the mixture was cooled to 0° C. The soluble part of the mixture was separated by filtration. Evaporation of the solvent afforded a solid mixture product, which was separated and purified by silica flash column chromatography using hexane to hexane/EtOAC (1:4, v/v) subsequently. The product was obtained as an off-white powder with a yield of 42%. The compound was characterized by 1H NMR and FT-IR.

Provenance & Evidence