1,4-Dioxane hydrochloride → H-L-Ile-D-Pro-OBzl

Participants

Reaction Steps

The compound Boc-L-Ile-D-Pro-OBzl (967 mg, 2.31 mmol) obtained in step 12-3 was dissolved in dioxane (12 ml) and 4N HCl/dioxane (12 ml) was added and the mixture was allowed to stand at room temperature for 1.5 hours. The reaction mixture was concentrated and diethyl ether/petroleum ether (1/3) was added to the residue followed by decantation to yield H-L-Ile-D-Pro-OBzl (745 mg, 91%).

Provenance & Evidence