Isoxazole-5-carbonyl chloride → HCID 22478409, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 18, 6-amino-4-(3-chloro-4-fluoroanilino)quinazoline was reacted with 5-isoxazolecarbonyl chloride to give 4-(3-chloro-4-fluoroanilino)-6-(isoxazole-5-carboxamido)quinazoline hydrochloride salt in 87% yield, m.p. >250° C.; NMR Spectrum: 7.4 (d, 1H), 7.5 (t, 1H), 7.65 (m, 2H), 8.0 (m, 2H), 8.85 (d, 1H), 8.9 (s, 1H), 11.4 (s, 1H); Elemental Analysis: Found C, 50.8; H, 3.3; N, 16.3; C18H11ClFN5O2 1HCl 0.4H2O 0.24DMA requires C, 50.8; H, 3.4; N, 16.4%.

Provenance & Evidence