6-Bromomethyl-4-(3-methylanilino)quinazoline → HCID 22478403, compound

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Reaction Steps

Using an analogous procedure to that described in Example 34, 6-bromomethyl-4-(3-methylanilino)quinazoline was reacted with 2-mercaptobenzimidazole sodium salt to give 6-(2-benzimidazolylthiomethyl)4-(3-methylanilino)quinazoline in 59% yield, m.p. 123-129° C.; NMR Spectrum: 2.34 (s, 3H), 4.77 (s, 2H), 6.96 (d, 1H), 7.13 (m, 2H), 7.28 (t, 1H), 7.46 (broad s, 2H), 7.68 (m, 3H), 7.96 (m, 1H), 8.57 (s, 1H), 8.65 (d, 1H), 9.79 (broad s, 1H); Elemental Analysis: Found C, 64.9; H, 5.3; N, 15.9; C23H19N5S 1.6H2O 0.1CH3OH requires C, 64.5; H, 5.3; N, 16.3%.

Provenance & Evidence