HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-Chloro-6H-thieno[2,3-b]pyrrole-5-carboxylic acid [(1S)-benzyl-2-morpholin-4-yl-2-oxo-ethyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| Reactant | 2-Chloro-6H-thieno[2,3-b]pyrrole-5-carboxylic acid | HCID 10442820 | — |
| Reactant | (2S)-amino-1-morpholin-4-yl-3-phenyl-propan-1-one hydrochloride | HCID 69749575 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Chloro-6H-thieno[2,3-b]pyrrole-5-carboxylic acid [(1S)-benzyl-2-morpholin-4-yl-2-oxo-ethyl]-amide | HCID 9866686 | — |
Reaction Steps
2-Chloro-6H-thieno[2,3-b]pyrrole-5-carboxylic acid and (2S)-amino-1-morpholin-4-yl-3-phenyl-propan-1-one hydrochloride (See, for example, Suzuki, K.; Fujita, H.; Sasaki, Y.; Shiratori, M.; Sakurada, S.; Kisara, K,. Chem. Pharm. Bull., 36, 4834-40 (1988)) were coupled according to Procedure C (solution of product in ethyl acetate washed with water, dried over MgSO4, concentrated).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06399601B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-387a9036aa354f57b6b06b1b5feec74b |
| Source note | uspto-grants-2002_06 |