Potassium Hydroxide → HCID 9908574, compound

Participants

Reaction Steps

Using a procedure analogous to that of G. M. Whitesides et al (J. Org. Chem., 53: 2489-2496 (1988)), to a solution of 2-trimethylsilanylethynyl-6H-thieno[2,3-b]pyrrole-5-carboxylic acid [(1S)-benzyl-2-(3-hydroxy-azetidin-1-yl)-2-oxo-ethyl]-amide (110 mg, 0.02 mmol) in methanol (0.5 ml) was added a 5% aqueous solution of potassium hydroxide (7 μL, 0.06 mmol). The reaction mixture was stirred for 3 h, concentrated to remove the methanol, diluted with water, and extracted with dichloromethane. The organic phase dried over MgSO4 and concentrated to give the title product (7 mg, 77%).

Provenance & Evidence