HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium hydroxide, monohydrate → 3-Chloro-4H-thieno[3,2-b]pyrrole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Ethyl 3-chloro-4H-thieno[3,2-b]pyrrole-5-carboxylate | HCID 57348924 | — |
| Product | 3-Chloro-4H-thieno[3,2-b]pyrrole-5-carboxylic acid | HCID 21906863 | — |
Reaction Steps
3-Chloro-4H-thieno[3,2-b]pyrrole-5-carboxylic acid ethyl ester was hydrolyzed according to Procedure F (7 equiv LiOH—H2O; room temperature overnight, then at 50° C. overnight again; addified aqueous phase extracted with ethyl acetate; combined organic phases dried over MgSO4, concentrated).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06399601B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-15ff168d3fca4249a9e3fd07c98098dd |
| Source note | uspto-grants-2002_06 |