Ammonium Chloride → 3-Bromo-4H-thieno[3,2-b]pyrrole-5-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

4-Bromo-thiophene-2-carbaldehyde was annulated according to Procedure H (aldehyde and azido-acetic acid ethyl ester added as ethanol solution (1.2 M of ester) such that reaction temperature maintained at 0° C.; reaction mixture allowed to warm to 10° C., stirred for 1 h, poured into cold saturated aqueous NH4Cl; after ether extractions, combined acrylate organic phases washed with water until aqueous phase was neutral; acrylate not purified).

Provenance & Evidence