HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → ETHYL 3-METHYL-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLATE
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Acetic acid, azido-, ethyl ester | HCID 69480 | — |
| Reactant | 4-methylthiophene-2-carbaldehyde | HCID 2795526 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | ETHYL 3-METHYL-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLATE | HCID 11651387 | — |
Reaction Steps
4-Methyl-thiophene-2carbaldehyde (Detty, M. R.; Hays, D. S., Heterocycles, 40: 925-37 (1995)) was annulated according to Procedure H (aldehyde and azido-acetic acid ethyl ester added as ethanol solution (1,1 M of ester); reaction poured into cold saturated aqueous NH4Cl; after ether extractions, acrylate organic phase washed with water until aqueous phase was neutral; acrylate not purified).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06399601B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-884808d86ce547feb70412c147d56bd7 |
| Source note | uspto-grants-2002_06 |