HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acrylate → HCID 67551065, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acrylate | HCID 25188 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Acetic acid, azido-, ethyl ester | HCID 69480 | — |
| Reactant | 1-Hydroxyethyl radical | HCID 119440 | — |
| Reactant | Thieno[2,3-b]thiophene-2-carboxaldehyde | HCID 3567708 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 67551065 | HCID 67551065 | — |
Reaction Steps
Thieno[2,3-b]thiophene-2-carbaldehyde (Dopper, J. H. et al., J. Am. Chem. Soc., 95: 3692-8 (1973)) was annulated according to Procedure H (aldehyde and azido-acetic acid ethyl ester added as ethanol solution (1 M of ester) to −20° C. ethoxide solution; −20° C. 30 min, −20° C. to room temperature over 2.5 h; reaction poured into cold saturated aqueous NH4Cl; after ether extraction, acrylate organic phase washed with water until aqueous phase was neutral; 0.35 M solution of crude acrylate heated).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06399601B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-01592aba8b8044f5b461e6c927a5303b |
| Source note | uspto-grants-2002_06 |