Dimethylamine → HCID 22457750, compound

Participants

Reaction Steps

Ethyl chloroformate (3.85g) was added to a solution of 3-{[2-(acetylamino)-ethylthio]methyl-4-oxo-4-(3-pyridyl)-butanoic acid (10 g) and triethylamine (4.88 g) in tetrahydrofuran (THF, 150 mL) at 0° C. The reaction mixture was stirred for 5 min. A 2M solution of dimethylamine in THF (17.7 mL) was added to the reaction mixture and stirred at room temperature for 2 hrs. The reaction mixture was concentrated and purified on HPLC (C-18 prep column, 10% to 90% acetonitrile in water both containing 0.1% TFA) to give 5.1 g of the title compound; ESMS (M+1)+338.

Provenance & Evidence