4-Fluorophenyl isocyanate → HCID 59894924, compound

HRID 2184734Notes

Reaction equation

HRID 2184734 reaction equation
C1C2C(CO[C:16]([NH:18][C@H:19]([C:36]([O:38][CH3:39])=[O:37])[CH2:20][S:21][CH2:22][CH:23]([C:28](=[O:35])[C:29]3[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=3)[CH2:24][C:25]([OH:27])=[O:26])=[O:17])C3C(=CC=CC=3)C=2C=CC=1.[F:40][C:41]1[CH:46]=[CH:45][C:44]([N:47]=C=O)=[CH:43][CH:42]=1>>[F:40][C:41]1[CH:46]=[CH:45][C:44]([NH:47][C:16]([NH:18][C@H:19]([C:36]([O:38][CH3:39])=[O:37])[CH2:20][S:21][CH2:22][CH:23]([C:28](=[O:35])[C:29]2[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=2)[CH2:24][C:25]([OH:27])=[O:26])=[O:17])=[CH:43][CH:42]=1

Participants

3

Reactant 2

HCID 709554-Fluorophenyl isocyanateHCID 70109626HCID 70109626, compound

Product 1

HCID 59894924HCID 59894924, compoundYield 5%

Procedure

The title compound was prepared from 3-({(2R)-2-[(fluoren-9-ylmethoxy)carbonylamino]-2-(methoxycarbonyl)ethylthio}methyl)-4-oxo-4-(3-pyridyl)butanoic acid and 4-fluorophenyl isocyanate as described in Example 16 in a 5% yield; ESMS, (M+1)+464.

Sources & evidence

ORD record
ord-450b18f2a4b24442b5e208b18200bd1c
Source dataset
uspto-grants-2002_06
Patent number
US06399606B1

Reaction notes

Loading…