5-Isocyanato-1,2,3-trimethoxybenzene → HCID 70112151, compound

HRID 2184737Notes

Reaction equation

HRID 2184737 reaction equation
C1C2C(CO[C:16]([NH:18][C@H:19]([C:36]([O:38][CH3:39])=[O:37])[CH2:20][S:21][CH2:22][CH:23]([C:28](=[O:35])[C:29]3[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=3)[CH2:24][C:25]([OH:27])=[O:26])=[O:17])C3C(=CC=CC=3)C=2C=CC=1.[CH3:40][O:41][C:42]1[CH:43]=[C:44]([N:52]=C=O)[CH:45]=[C:46]([O:50][CH3:51])[C:47]=1[O:48][CH3:49]>>[CH3:51][O:50][C:46]1[CH:45]=[C:44]([NH:52][C:16]([NH:18][C@H:19]([C:36]([O:38][CH3:39])=[O:37])[CH2:20][S:21][CH2:22][CH:23]([C:28](=[O:35])[C:29]2[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=2)[CH2:24][C:25]([OH:27])=[O:26])=[O:17])[CH:43]=[C:42]([O:41][CH3:40])[C:47]=1[O:48][CH3:49]

Participants

3

Reactant 2

HCID 5177665-Isocyanato-1,2,3-trimethoxybenzeneHCID 70109626HCID 70109626, compound

Product 1

HCID 70112151HCID 70112151, compoundYield 7.2%

Procedure

The title compound was prepared from 3-({(2R)-2-[(fluoren-9-ylmethoxy)carbonylamino]-2-(methoxycarbonyl)ethylthio}methyl)-4-oxo-4-(3-pyridyl)butanoic acid and 3,4,5-trimethoxyphenyl isocyanate as described in Example 16 in a 7.2% yield; ESMS, (M+1)+536.

Sources & evidence

ORD record
ord-b66ee184e306413ebe177b7ce8bd98de
Source dataset
uspto-grants-2002_06
Patent number
US06399606B1

Reaction notes

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