Cyclohexyl isocyanate → HCID 21340856, compound

HRID 2184739Notes

Reaction equation

C1C2C(CO[C:16]([NH:18][C@H:19]([C:36]([O:38][CH3:39])=[O:37])[CH2:20][S:21][CH2:22][CH:23]([C:28](=[O:35])[C:29]3[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=3)[CH2:24][C:25]([OH:27])=[O:26])=[O:17])C3C(=CC=CC=3)C=2C=CC=1.[CH:40]1([N:46]=C=O)[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1>>[CH:40]1([NH:46][C:16]([NH:18][C@H:19]([C:36]([O:38][CH3:39])=[O:37])[CH2:20][S:21][CH2:22][CH:23]([C:28](=[O:35])[C:29]2[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=2)[CH2:24][C:25]([OH:27])=[O:26])=[O:17])[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1

Participants

Reactant 2

HCID 18502Cyclohexyl isocyanate

HCID 70109626HCID 70109626, compound

Product 1

HCID 21340856HCID 21340856, compoundYield 6%

Procedure

The title compound was prepared from 3-({(2R)-2-[(fluoren-9-ylmethoxy)carbonylamino]-2-(methoxycarbonyl)ethylthio}methyl)-4-oxo-4-(3-pyridyl)butanoic acid and cyclohexyl isocyanate as described in Example 16 in a 6% yield; ESMS, (M+1)+452.

Sources & evidence

ORD record: ord-98253fd864e5482ba08723111a1af230
Source dataset: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06399606B1

Reaction notes

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