Cyclohexyl isocyanate → HCID 22457715, compound

HRID 2184744Notes

Reaction equation

[CH2:1]([NH:5][CH2:6][CH2:7][S:8][CH2:9][CH:10]([C:17](=[O:24])[C:18]1[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=1)[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:2][CH2:3][CH3:4].[CH:25]1([N:31]=[C:32]=[O:33])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>>[CH2:1]([N:5]([C:32]([NH:31][CH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1)=[O:33])[CH2:6][CH2:7][S:8][CH2:9][CH:10]([C:17](=[O:24])[C:18]1[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=1)[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 18502Cyclohexyl isocyanate

HCID 22457757HCID 22457757, compound

Product 1

HCID 22457715HCID 22457715, compoundYield 48%

Procedure

The title compound was prepared from ethyl 3 {[2-(butylamino)ethylthio] methyl}-4-oxo-4-(3-pyridyl)butanoate and cyclohexylisocyanate as described in the above Example 35 in 48% yield; ESMS (M+1+) 478.

Sources & evidence

ORD record: ord-11912498afea4fab99083e1e8259e705
Source dataset: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06399606B1

Reaction notes

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