HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Ethoxy-5-nitropyridine → 6-Ethoxypyridin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Ethoxy-5-nitropyridine | HCID 295864 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-Ethoxypyridin-3-amine | HCID 3040301 | 97.8% |
Reaction Steps
A mixture of 2-ethoxy-5-nitropyridine (3.60 g) and 10% Pd/C (360 mg) in ethanol (40 mL) was placed in a Paar bottle and shaken under hydrogen (50 PSI) for 16 h. The mixture was filtered through Celite using dichloromethane and concentrated to give 2.892 g of 2-ethoxy-5-aminopyridine as a gold solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06399604B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-7ab8a3208cbc4bbcbf34d255cbac2967 |
| Source note | uspto-grants-2002_06 |